清晨好,您是今天最早来到科研通的研友!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您科研之路漫漫前行!

Platelet Count Rose While D-Dimer Levels Dropped as Deaths and Thrombosis Declined—An Observational Study on Anticoagulation Shift in COVID-19

医学 血栓形成 优势比 内科学 肺栓塞 血小板 置信区间 D-二聚体 回顾性队列研究 队列 队列研究 静脉血栓形成 外科 胃肠病学
作者
Anna Sjöström,Johanna Dehlsen Wersäll,Anna Warnqvist,Maria Farm,Maria Magnusson,Anders Oldner,Anna Ågren,Jovan Antović,Maria Bruzelius
出处
期刊:Thrombosis and Haemostasis [Thieme Medical Publishers (Germany)]
卷期号:121 (12): 1610-1621 被引量:21
标识
DOI:10.1055/a-1477-3829
摘要

Abstract Background High levels of D-dimer and low platelet counts are associated with poor outcome in coronavirus disease 2019 (COVID-19). As anticoagulation appeared to improve survival, hospital-wide recommendations regarding higher doses of anticoagulation were implemented on April 9, 2020. Objectives To investigate if trends in D-dimer levels and platelet counts were associated with death, thrombosis, and the shift in anticoagulation. Methods Retrospective cohort study of 429 patients with COVID-19 at Karolinska University Hospital. Information on D-dimer levels and platelet counts was obtained from laboratory databases and clinical data from medical records. Results Thirty-day mortality and thrombosis rates were 19% and 18%, respectively. Pulmonary embolism was common, 65/83 (78%). Increased D-dimer levels in the first week in hospital were significantly associated with death and thrombosis (odds ratio [OR]: 6.06; 95% confidence interval [CL]: 2.10–17.5 and 3.11; 95% CI: 1.20–8.10, respectively). If platelet count increased more than 35 × 109/L per day, the mortality and thrombotic risk decreased (OR: 0.16; 95% CI: 0.06–0.41, and OR: 0.36; 95% CI: 0.17–0.80). After implementation of updated hospital-wide recommendations, the daily mean significantly decreased regarding D-dimer levels while platelet counts rose; −1.93; 95% CI: −1.00–2.87 mg/L FEU (fibrinogen-equivalent unit) and 65; 95% CI: 54–76 ×109/L, and significant risk reductions for death and thrombosis were observed; OR: 0.48; 95% CI: 0.25–0.92 and 0.35; 95% CI: 0.17–0.72. Conclusion In contrast to D-dimer levels, increase of platelet count over the first week in hospital was associated with improved survival and reduced thrombotic risk. The daily mean levels of D-dimer dropped while the platelet counts rose, coinciding with increased anticoagulation and a decline in thrombotic burden and mortality.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
济民财完成签到,获得积分10
14秒前
16秒前
18秒前
zhangxuhns发布了新的文献求助10
21秒前
幽默滑板完成签到,获得积分10
21秒前
彩色的芷容完成签到 ,获得积分10
21秒前
小甑发布了新的文献求助10
25秒前
无忧sxt完成签到 ,获得积分10
33秒前
燕子完成签到 ,获得积分10
41秒前
zhdjj完成签到 ,获得积分10
45秒前
小甑完成签到,获得积分10
48秒前
陈无敌完成签到 ,获得积分10
48秒前
zhangxuhns完成签到,获得积分10
55秒前
theo完成签到 ,获得积分10
1分钟前
淡淡菠萝完成签到 ,获得积分10
1分钟前
耕牛热完成签到,获得积分10
1分钟前
1分钟前
科研通AI6应助奥丁和海拉采纳,获得30
1分钟前
认真一斩发布了新的文献求助10
2分钟前
shining完成签到,获得积分10
2分钟前
空咻咻发布了新的文献求助20
2分钟前
平常的三问完成签到 ,获得积分10
2分钟前
空咻咻完成签到,获得积分10
2分钟前
lx完成签到,获得积分10
2分钟前
gmc完成签到 ,获得积分10
3分钟前
zzhui完成签到,获得积分10
3分钟前
huanghe完成签到,获得积分10
3分钟前
科研的豪哥完成签到 ,获得积分10
3分钟前
kenchilie完成签到 ,获得积分10
3分钟前
zzgpku完成签到,获得积分0
3分钟前
CHANG完成签到 ,获得积分10
3分钟前
奋斗的雪曼完成签到,获得积分10
3分钟前
bo完成签到 ,获得积分10
3分钟前
红毛兔完成签到 ,获得积分10
3分钟前
fogsea完成签到,获得积分0
3分钟前
iwsaml完成签到 ,获得积分10
4分钟前
捡子完成签到 ,获得积分10
4分钟前
yml完成签到 ,获得积分10
4分钟前
V_I_G完成签到 ,获得积分10
4分钟前
一盏壶完成签到,获得积分10
4分钟前
高分求助中
(应助此贴封号)【重要!!请各位详细阅读】【科研通的精品贴汇总】 10000
Revision of the Australian Thynnidae and Tiphiidae (Hymenoptera) 500
Instant Bonding Epoxy Technology 500
Pipeline Integrity Management Under Geohazard Conditions (PIMG) 500
Methodology for the Human Sciences 500
DEALKOXYLATION OF β-CYANOPROPIONALDEYHDE DIMETHYL ACETAL 400
Assessment of adverse effects of Alzheimer's disease medications: Analysis of notifications to Regional Pharmacovigilance Centers in Northwest France 400
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4360438
求助须知:如何正确求助?哪些是违规求助? 3861865
关于积分的说明 12044504
捐赠科研通 3503925
什么是DOI,文献DOI怎么找? 1923004
邀请新用户注册赠送积分活动 965253
科研通“疑难数据库(出版商)”最低求助积分说明 864684