瘤胃球菌
厚壁菌
拟杆菌
双歧杆菌
肠道菌群
抗性淀粉
封堵器
拟杆菌
食品科学
代谢物
生物化学
化学
饮食性肥胖
生物
微生物学
肥胖
胰岛素抵抗
内科学
内分泌学
淀粉
细菌
乳酸菌
紧密连接
医学
发酵
遗传学
16S核糖体RNA
基因
作者
Dan Liang,Liang Zhang,Hongzhu Chen,Hong Zhang,Honghai Hu,Xiaofeng Dai
标识
DOI:10.1016/j.ijbiomac.2021.02.209
摘要
Potato resistant starch type 3 (PRS) is helpful for weight-loss. To investigate the regulatory effects of PRS on high-fat diet (HFD)-induced obesity, different doses of PRS (5%, 15% and 25%) were fed to mice for 12 weeks. Metabolic syndrome related to obesity, intestinal microbiota composition and its metabolites as well as the relationship among them were studied. Results showed that PRS could regulate HFD-induced metabolic syndrome in a dose dependent manner; promote the proliferation of intestinal cells and expression of tight junction proteins, such as Occludin and zonula occludens (ZO)-1; reduce the Firmicutes/Bacteroidetes (F/B) rate; regulate the relative abundance of intestinal microbiota, such as Bifidobacterium, Ruminococcus, Bacteroides and Coprococcus; and promote the production of microbial metabolites, such as propionic acid and acetic acid. Besides, the alteration in the intestinal microbiota composition and metabolites were significantly correlated. It could be concluded that propionic acid and acetic acid were the two dominant metabolites of Bifidobacterium, Ruminococcus, Bacteroides, and Coprococcus, which contributed to the anti-obesity potential of PRS, metabolic syndrome alleviation, and intestinal barrier dysfunction.
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