化学
对映体药物
二醇
萘
动力学分辨率
环烷烃
催化作用
脱氢酶
区域选择性
药物化学
立体选择性
有机化学
立体化学
酶
对映选择合成
作者
Derek R. Boyd,Narain D. Sharma,M. Victoria Berberian,Marcel Cleij,Christopher Hardacre,Vera Ljubez,Gareth McConville,Paul J. Stevenson,Leonid Kulakov,Christopher C. R. Allen
标识
DOI:10.1002/adsc.201500189
摘要
Abstract Benzene cis ‐ diol dehydrogenase and naphthalene cis ‐diol dehydrogenase enzymes, expressed in Pseudomonas putida wild‐type and Escherichia coli recombinant strains, were used to investigate regioselectivity and stereoselectivity during dehydrogenations of arene, cyclic alkane and cyclic alkene vicinal cis ‐diols. The dehydrogenase‐catalysed production of enantiopure cis ‐diols, α‐ketols and catechols, using benzene cis ‐ diol dehydrogenase and naphthalene cis ‐diol dehydrogenase, involved both kinetic resolution and asymmetric synthesis methods. The chemoenzymatic production and applications of catechol bioproducts in synthesis were investigated. magnified image
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