肿瘤抑制因子
多发性硬化
免疫系统
白血病抑制因子
细胞因子
免疫学
糖蛋白130
信号转导
实验性自身免疫性脑脊髓炎
生物
白细胞介素6
发病机制
自身免疫性疾病
神经科学
医学
抗体
细胞生物学
作者
Kris Janssens,Helena Slaets,Niels Hellings
摘要
Multiple sclerosis (MS) is a chronic disabling autoimmune disease of the central nervous system. The interleukin (IL)-6 cytokine family plays a crucial role in regulating the immune response in MS. All members of the IL-6 family share the common signal-transducing receptor protein, glycoprotein 130. Although the intracellular signaling of these cytokines seems to be largely overlapping, they have diverse and contrasting effects on the immune response. This review focuses on the effects of the family members IL-6, leukemia inhibitory factor, oncostatin M, and IL-11 on immune cell subsets and how these effects relate to the pathogenesis of MS. Finally, we propose possible avenues to modulate these family members for future MS therapy.
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