斑马鱼
生物
造血
模式生物
干细胞
造血干细胞
脊椎动物
细胞生物学
有机体
干细胞生物学
发育生物学
进化生物学
遗传学
基因
胚胎
胚胎发生
生殖技术
作者
Jenna M. Frame,Sung-Eun Lim,Trista E. North
标识
DOI:10.1016/bs.mcb.2016.08.004
摘要
Hematopoietic stem cells (HSCs) reside at the apex of the hematopoietic hierarchy, giving rise to each of the blood lineages found throughout the lifetime of the organism. Since the genetic programs regulating HSC development are highly conserved between vertebrate species, experimental studies in zebrafish have not only complemented observations reported in mammals but have also yielded important discoveries that continue to influence our understanding of HSC biology and homeostasis. Here, we summarize findings that have established zebrafish as an important conserved model for the study of hematopoiesis, and describe methods that can be utilized for future investigations of zebrafish HSC biology.
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