Myeloid p53 regulates macrophage polarization and venous thrombus resolution by inflammatory vascular remodeling in mice

Key Points Endogenous p53 within myeloid cells regulates venous thrombus resolution, intrathrombus macrophage polarization, and fibrosis. The p53 agonist quinacrine accelerates resolution of established venous thrombus, a potential translational benefit in patients with DVT.