ChemInform Abstract: A Novel Route to 6‐Perfluoroalkyluracils.

Abstract Reaction of the 2,4‐dichloropyrimidines (I) with perfluoroalkyllithiums generated in situ from the iodides (II) gives the 4‐perfluoroalkyldihydropyrimidines (III) which are converted to the 6‐perfluoroalkyl‐5,6‐dihydrouracils (IV) by hydrolysis or to the 6‐perfluoroalkyluracils (VIII) by oxidation with DDQ and subsequent hydrolysis.