Abstract PR10: Hippo regulates intestinal regeneration by inducing revival stem cells

Abstract The mechanisms underlying intestinal regeneration and initiation of adenomas have been obscure. Here we profiled the single-cell transcriptomes of regenerating intestines and identify revival stem cells. Revival stem cells are dependent on Yap signaling, are transiently induced by a variety of damage, and are required to reconstitute the intestinal crypt. These studies reveal a unique pathway to regenerate damaged tissues. This abstract is also being presented as Poster A14. Citation Format: Arshad Ayyaz, Jeff Wrana. Hippo regulates intestinal regeneration by inducing revival stem cells [abstract]. In: Proceedings of the AACR Special Conference on the Hippo Pathway: Signaling, Cancer, and Beyond; 2019 May 8-11; San Diego, CA. Philadelphia (PA): AACR; Mol Cancer Res 2020;18(8_Suppl):Abstract nr PR10.