[Lectins and glycoconjugates in presentation of antigens and protection against patogens.]

The current data on using lectin receptors and glycoconjugates (GC) in study of pathways of intercellular communications within innate immunity network coupled to adaptive immunity wеre overviewed and systematized. A superfamily of GC-specific C-type lectin receptors (CLR), as a constituent of pattern recognizing receptors (PRR), involves in immunity to produce redistribution of groups of cytokines, chemokines and specific antibodies. CLR on surface of multiple subpopulations of antigen-presenting cells (APC) and other cells of immunity are under consideration (monocyte derived macrophages, macrophages, immature and mature dendritic cells, other myeloid cells, neutrophils, basophils, lymphocytes, etc.). CLR cofunction both each other and/or together with other PRR and immune receptors. CLR are favourable for quicker and GC-specific innate type presentation of important danger antigenic patterns (PAMP, MAMP, DAMP, SAMP, TAMP) using their specific targeting through currently/ adaptively optimal pathways within intercellular branched network of activated/ polarized subpopulations of cells mentioned above. CLR agonist GC (recombinant, synthetic, conjugates to carriers (adaptive proteins, etc.), assembled into nanoparticles and liposomes) can serve successful and specific adjuvants in vaccine strategies. CLR and GC pairs participate in on duty biocontrol of immunobiological supervising in organism, modulate/ switch recognition and protection cell pathways of immune responses (presentation, reciprocally organized protective attacks, rates and amplitudes of activation and inhibition of cell communicative chains). Lectins characterized both cell and cell communicative chain current functional biomarkering that is of importance for clinical diagnostics. The knowledge on CLR-GC pattern relationships is perspective for study and influence fine mechanisms of cell GC-targeting and immunity, improvement of traditional vaccines, development of GC-specific and highly effective pattern vaccines against different infections or tumors. New specific vaccine strategies are possible towards different biotopes in organism (also for mucosal opened cavities).