脂肪变性
营养不良
脂肪肝
背景(考古学)
非酒精性脂肪肝
肠道菌群
生理学
肥胖
医学
微生物群
疾病
生物
内科学
生物信息学
免疫学
古生物学
作者
Kylynda C. Bauer,Kelsey E. Huus,Eric Brown,Tahereh Bozorgmehr,Charisse Petersen,Mihai Cirstea,Sarah E. Woodward,John J. McCoy,Jeong Ki Hun,Reinald Pamplona,Victòria Ayala,B. Brett Finlay
出处
期刊:MSystems
[American Society for Microbiology]
日期:2020-10-27
卷期号:5 (5)
被引量:4
标识
DOI:10.1128/msystems.00499-20
摘要
Nonalcoholic fatty liver disease (NAFLD) remains a global epidemic, but it is often studied in the context of obesity and aging. Nutritional deficits, however, also trigger hepatic steatosis, influencing health trajectories in undernourished pediatric populations. Here, we report that exposure to specific gut microbes impacts fatty liver pathology in mice fed a protein/fat-deficient diet. We utilize a multiomics approach to (i) characterize NAFLD in the context of early undernutrition and (ii) examine the impact of diet and gut microbes in the pathology and reversal of hepatic steatosis. We provide compelling evidence that an early-life, critical development window facilitates undernutrition-induced fatty liver pathology. Moreover, we demonstrate that sustained dietary intervention largely reverses fatty liver features and microbiome shifts observed during early-life malnutrition.
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