Sex-specific associations of plasma metals and metal mixtures with glucose metabolism: An occupational population-based study in China

百分位 化学 内科学 内分泌学 医学 无机化学 数学 统计 有机化学
作者
Xiaoting Ge,Aimin Yang,Sifang Huang,Xiaoyu Luo,Qingzhi Hou,Lulu Huang,Yanting Zhou,Defu Li,Yingnan Lv,Longman Li,Hong Cheng,Xiang Chen,Gaohui Zan,Yanli Tan,Chaoqun Liu,Lili Xiao,Yunfeng Zou,Xiaobo Yang
出处
期刊:Science of The Total Environment [Elsevier BV]
卷期号:760: 143906-143906 被引量:43
标识
DOI:10.1016/j.scitotenv.2020.143906
摘要

Studies with multi-pollutant approach on the relationships between multiple metals and fasting plasma glucose (FPG) are limited. Few studies are available on the potential sex-specific associations between metal exposures and glucose metabolism. We explored the associations between 22 plasma metals and FPG level among the 769 participants from the manganese-exposed workers healthy cohort in China. We applied a sparse partial least squares (sPLS) regression followed by ordinary least-squares regression to evaluate multi-pollutant association. Bayesian kernel machine regression (BKMR) model was used to deal with metal mixtures and evaluate their joint effects on FPG level. In the sPLS model, negative associations on FPG levels were observed for plasma iron (belta = −0.066), cobalt (belta = −0.075), barium (belta = −0.109), and positive associations for strontium (belta = 0.082), and selenium (belta = 0.057) in men, which overlapped with the results among the overall participants. Among women, plasma copper (belta = 0.112) and antimony (belta = 0.137) were positively associated with elevated FPG level. Plasma magnesium was negatively associated with FPG level in both sexes (belta = −0.071 in men and belta = −0.144 in women). The results of overlapped for plasma magnesium was selected as the significant contributor to decreasing FPG level in the multi-pollutant, single-metal, and multi-metal models. BKMR model showed a significantly negative over-all effect of six metal mixtures (magnesium, iron, cobalt, selenium, strontium and barium) on FPG level among the overall participants from all the metals fixed at 50th percentile. In summary, our findings underline the probable role of metals in glucose homeostasis with potential sex-dependent heterogeneities, and suggest more researches are needed to explore the sex-specific associations of metal exposures with risk of diabetes.
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