乌斯特基努马
白细胞介素23
炎症性肠病
医学
免疫学
疾病
抗体
白细胞介素
细胞因子
肿瘤坏死因子α
内科学
英夫利昔单抗
出处
期刊:Chin J Inflamm Bowel Dis
日期:2020-01-25
卷期号:04 (01): 16-19
标识
DOI:10.3760/cma.j.issn.2096-367x.2020.01.005
摘要
The heterodimeric cytokines IL-12 and IL-23, composed of a shared p40 subunit, play a key role in T helper cell and innate lymphocyte cell differentiation and expansion. Studies demonstrated that IL-12 and IL-23 played a pivotal role in inflammatory bowel disease. Here we review the immunological background to anti-IL-12/IL-23-directed therapeutic strategies and latest research updates.
Key words:
Inflammatory bowel disease; Interlukin-12; Interlukin-23; Ustekinumab; Biologics
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