骨整合
生物相容性
材料科学
阳离子聚合
模拟体液
表面改性
生物医学工程
纳米技术
抗菌活性
植入
化学工程
高分子化学
复合材料
医学
外科
细菌
生物
工程类
冶金
遗传学
扫描电子显微镜
作者
Yujie Sun,Yuqing Zhao,Qiang Zeng,Yuwei Wu,Yang Hu,Shun Duan,Ziyang Tang,Fu‐Jian Xu
标识
DOI:10.1021/acsami.9b14572
摘要
Multifunctional antibacterial materials have great significance for treating biomedical device-associated infections (BAIs). In the present work, a facile and rational strategy was developed to produce dual-functional implants with antibacterial and osteointegration-promoting properties for the treatment of BAI. A titanium implant, as a representative demo of implants, was first functionalized with ethanediamine-functionalized poly(glycidyl methacrylate) (PGED) brushes. Then, low-molecular-weight quaternized polyethyleneimine (QPEI, a cationic antibacterial agent) and alendronate (ALN, a clinically used drug with high affinity for bone minerals) were covalently conjugated onto PGED brushes to produce dual-functional dental implants (Ti-AQ). The QPEI component imparted Ti-AQ with antibacterial abilities, and the ALN component could balance the cytotoxicity of a cationic antibacterial agent, improving the biocompatibility for osteoblast cells. The effective performances of anti-infection and osteointegration were demonstrated in a BAI animal model. The results indicated that Ti-AQ inhibited bacterial infection at the early stage and enhanced the osteointegration and biomechanical properties between the implants and bone tissues at the late stage. This study will provide one facile and universal strategy for the design and development of novel multifunctional antibacterial implants.
科研通智能强力驱动
Strongly Powered by AbleSci AI