化学选择性
羟基化
光催化
化学
杂原子
反应性(心理学)
组合化学
酶
催化作用
生物催化
立体化学
有机化学
反应机理
光催化
戒指(化学)
医学
替代医学
病理
作者
Rick C. Betori,Catherine M. May,Karl A. Scheidt
标识
DOI:10.1002/anie.201909426
摘要
Abstract Chemical transformations that install heteroatoms into C−H bonds are of significant interest because they streamline the construction of value‐added small molecules. Direct C−H oxyfunctionalization, or the one step conversion of a C−H bond to a C−O bond, could be a highly enabling transformation due to the prevalence of the resulting enantioenriched alcohols in pharmaceuticals and natural products,. Here we report a single‐flask photoredox/enzymatic process for direct C−H hydroxylation that proceeds with broad reactivity, chemoselectivity and enantioselectivity. This unified strategy advances general photoredox and enzymatic catalysis synergy and enables chemoenzymatic processes for powerful and selective oxidative transformations.
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