结晶
过饱和度
D-甘露醇
结晶学
溶解
化学工程
经典成核理论
材料科学
分析化学(期刊)
作者
Weiyi Su,Hongxun Hao,Brian Glennon,Mark Barrett
摘要
The spontaneous nucleation of d-mannitol polymorphs at different initial concentrations in an aqueous solution was investigated. Two in situ process analytical technology (PAT) tools, Raman spectroscopy and focused beam reflectance measurement (FBRM), were combined to monitor the process, allowing instantaneous detection of polymorphs after nucleation. It was found that the stable β form of mannitol was favored at low initial concentrations, whereas the metastable α form nucleated at high concentrations and the metastable δ polymorph crystallized when the concentration was in the medium level. To help understand this phenomenon, the thermodynamic and kinetic characteristics of different polymorphs were analyzed. The solubility of the two metastable forms was determined by an innovative method with the aid of Raman spectroscopy, whereas the interfacial energy between polymorphs and the bulk solution were obtained from the induction time measurements. Consequently, the critical excess free energy and other ...
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