Labor analgesia creates a safe and painless environment for labor process.Ideal medicine for analgesia labor should have obvious effect and minimum influence on mothers and neonates.Sufentanil is a synthetic opioid drug which has strong analgesic effect,long effective time and less side effect.Sufentanil is widely used in clinical application because of its unique pharmacological features.Here is to review on the sufentanil pharmacology features,clinical application in labor analgesia by intrathecal and epidural pipe and its impact on mothers and neonates,so as to understand and evaluate sufentanil in labor analgesia.