A study of relationship between serum concentration of risperidone and clinical effects and side effects.

Objective To study the relationship between serum concentration of risperidone and clinical effects and side effects in treatment of patients with schizophrenia,and to determine the treatment range of risperidone.MethodsA total of 52 schizophrenic inpatients (28 male, 24 female) were evaluated before and after treatment with PANSS,TESS,ESRS.HPLC was used to measure the concentration of risperidone at week 4,8 after treatment with risperidone.ResultsThe serum concentrations at week 4,8 after treatment with risperidone (2~8mg/d) were (37.68±15.26)nmol/l and (49.21±16.23)nmol/l. Serum concentration of risperidone was significantly related to PANSS,TESS,ESRS.When serum concentration of risperidone was over 65nmol/l, clinical effects did not improve with the increased dosage,but the side effects increased.ConlusionRisperidone is safe and effective when the drug dosage is (2~6)mg/d and serum concentration is (30~65)nmol/l.