Expression and significance of STAT3 protein in prostate cancer tissues

Objective:To explore the expression and significance of signal transducer and activator of transcription 3(STAT3) in prostate carcinoma tissues.Methods:The expression of STAT3 in 40 cases of prostate carcinoma tissues and 12 cases of normal prostate tissue was detected by immunohistochemical staining.Results:The positive rate of the expression of STAT3 in prostate carcinoma was 87.5%,and was significantly higher than 41.7% in the normal prostate tissue,there was a significant difference between two groups(P0.01).STAT3 expression levels were closely related to the pathological grade of prostate cancer.Conclusion:Compared with the normal prostate tissue,the expression level of STAT3 in prostate carcinoma is significantly higher.It suggests that the expression of STAT3 may be related to the risk and develop-ment of prostate carcinoma.