Pharmacokinetics of Tinidazole Tablet in Muslim and Han Healthy Volunteers

OBJECTIVE:To study the pharmacokinetics of single oral dose of tinidazole tablet in Muslim and Han healthy volunteers.METHODS:Twenty volunteers(10 Muslim and 10 Han volunteers,with the ratio of male:female at 1∶1),Each subject received a single dose of 1 g tinidazole tablet.The plasma concentrations of tinidazole were determined by HPLC.The pharmacokinetics parameters were treated by DAS software and analyzed statistically by SPSS software.RESULTS:The main pharmacokinetics parameters of Muslim were as follows:Cmax(20.25±4.05)μg·mL-1,tmax(2.10±0.66)h,t1/2(16.81±1.56)h,AUC0～72(483.51±116.83)mg·h·L-1,and AUC0～∞(514.25±130.78).The main pharmacokinetics parameters of Han were as follows:Cmax(19.04±2.42)μg·mL-1,tmax(2.15±0.47)h,t1/2(16.94±2.40)h,AUC0～72(454.37±59.74)mg·h·L-1 and AUC0～∞(486.14±65.63)mg·h·L-1.The main pharmacokinetics parameters of Male were as follows:Cmax(17.16±1.28)μg·mL-1,tmax(2.20±0.59)h,t1/2(17.32±1.97)h,AUC0～72(406.83±44.40)mg·h·L-1 and AUC0～∞(437.11±54.73).The main pharmacokinetics parameters of Female were as follows:Cmax(22.12±2.79)μg·mL-1,tmax(2.05±0.55)h,t1/2(16.43±1.97)h,AUC0～72(531.05±84.54)mg·h·L-1 and AUC0～∞(563.27±100.06)mg·h·L-1.CONCLUSION:The results showed that the main pharmacokinetics parameters of tinidazole have no significant differences between Muslim and Han,but have significant differences between male and female.