化学
酰胺
硝基苯
氢键
戒指(化学)
药物化学
质子磁共振
质子核磁共振
质子
共振(粒子物理)
芳香性
硝基
生物催化
立体化学
有机化学
反应机理
分子
核磁共振
催化作用
物理
烷基
量子力学
粒子物理学
摘要
A number of 2-substituted 1,3-phenylenediamines and their N-acyl and N,N?-diacyl derivatives have been prepared and the proton magnetic resonance spectra examined for evidence that hydrogen bonding between the amide protons and the 2-substituents can occur so as to constrain two amido groups to coplanarity with the aromatic ring. The nitro and methylsulphonyl substituents behave in this way. Weaker, but still effective, dual hydrogen bonding to methoxycarbonyl, chloro, methoxy, and methylthio substituents is observed. A new technique is described for performing the Hoffman degradation of the bis-amide of 2- nitroisophthalic acid to 1,3-diamino-2-nitrobenzene.
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