材料科学
自愈水凝胶
右旋糖酐
化学工程
分散性
甲基丙烯酸酯
模板
纳米凝胶
多孔性
纳米技术
细胞包封
微流控
共聚物
药物输送
高分子化学
化学
聚合物
复合材料
色谱法
工程类
作者
Selin Bulut,Se‐Hyeong Jung,Thomas Bissing,Florian Schmitt,Michelle Bund,Susanne Braun,Andrij Pich
出处
期刊:Small
[Wiley]
日期:2023-07-11
卷期号:19 (45)
被引量:1
标识
DOI:10.1002/smll.202303783
摘要
Hydrogels, as well as colloidal hydrogels (microgels), are important materials for a large variety of applications in the biomedical field. Microgels with a controlled pore size (meso- and macropores) are required for efficient nutrient support, modulation of cell adhesion, removal of metabolic products in cell cultures, and probiotic loading. Common microgel fabrication techniques do not provide sufficient control over pore sizes and geometry. In this work, the natural polysaccharide dextran modified with methacrylate groups is used to synthesize highly monodisperse meso- and macroporous microgels in a size range of 100-150 µm via photo cross-linking in microfluidic droplets. The size of mesopores is varied by the concentration of dextran methacrylate chains in the droplets (50-200 g L-1 ) and the size of macropores is regulated by the integration of pH-degradable supramacromolecular nanogels with diameters of 300 and 700 nm as sacrificial templates. Using permeability assays combined with confocal laser scanning microscopy, it is demonstrated that functional dextran-based microgels with uniform and defined pores could be obtained.
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