白质
心理学
神经科学
精神分裂症(面向对象编程)
磁共振成像
认知
精神病
灰色(单位)
听力学
医学
精神科
放射科
作者
Haruko Kobayashi,Daiki Sasabayashi,Tsutomu Takahashi,Atsushi Furuichi,Mikio Kido,Yoichiro Takayanagi,Kyo Noguchi,Michio Suzuki
标识
DOI:10.1093/cercor/bhae009
摘要
Abstract Previous postmortem brain studies have revealed disturbed myelination in the intracortical regions in patients with schizophrenia, possibly reflecting anomalous brain maturational processes. However, it currently remains unclear whether this anomalous myelination is already present in early illness stages and/or progresses during the course of the illness. In this magnetic resonance imaging study, we examined gray/white matter contrast (GWC) as a potential marker of intracortical myelination in 63 first-episode schizophrenia (FESz) patients and 77 healthy controls (HC). Furthermore, we investigated the relationships between GWC findings and clinical/cognitive variables in FESz patients. GWC in the bilateral temporal, parietal, occipital, and insular regions was significantly higher in FESz patients than in HC, which was partly associated with the durations of illness and medication, the onset age, and lower executive and verbal learning performances. Because higher GWC implicates lower myelin in the deeper layers of the cortex, these results suggest that schizophrenia patients have less intracortical myelin at the time of their first psychotic episode, which underlies lower cognitive performance in early illness stages.
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