补体系统
基因
疾病
补语(音乐)
免疫系统
经典补体途径
计算生物学
痴呆
补体因子B
医学
生物信息学
神经学
生物
免疫学
神经科学
遗传学
内科学
表型
互补
作者
Xi-Chen Zhu,Boyu Tang,Meng-Zhuo Zhu,Jing Lü,Honghuang Lin,Jiaming Tang,Rong Li,Tengfei Ma
出处
期刊:BMC Neurology
[Springer Nature]
日期:2023-12-19
卷期号:23 (1)
被引量:1
标识
DOI:10.1186/s12883-023-03503-0
摘要
Abstract Alzheimer’s disease (AD) is a primary cause of dementia. The complement system is closely related to AD pathology and may be a potential target for the prevention and treatment of AD. In our study, we conducted a bioinformatics analysis to analyze the role of the complement system and its related factors in AD using Gene Expression Omnibus (GEO) data. We also conducted a functional analysis. Our study verified that 23 genes were closely related to differentially expressed complement system genes in diseases after intersecting the disease-related complement system module genes and differentially expressed genes. The STRING database was used to predict the interactions between the modular gene proteins of the differential complement system. A total of 21 gene proteins and 44 interaction pairs showed close interactions. We screened key genes and created a diagnostic model. The predictive effect of the model was constructed using GSE5281 and our study indicated that the predictive effect of the model was good. Our study also showed enriched negative regulation of Notch signaling, cytokine secretion involved in the immune response pathway, and cytokine secretion involved in immune response hormone-mediated apoptotic signaling pathway. We hope that our study provides a promising target to prevent and delay the onset, diagnosis, and treatment of AD.
科研通智能强力驱动
Strongly Powered by AbleSci AI