磁共振成像
成像体模
电流
材料科学
生物医学工程
电阻率和电导率
核磁共振
生物系统
生物物理学
纳米技术
生物
物理
医学
光学
放射科
电气工程
量子力学
工程类
作者
Guofang Xu,H. Liu,Yinhao Ren,Yupeng Liao,Feng Liu,Xiang Nan,Jijun Han
摘要
The electrical properties of human tissue have significant potential as biophysical markers in clinical applications, as they can indicate biochemical/biophysical changes occurring at the cellular and extracellular levels. Magnetic resonance electrical properties tomography (MR-EPT) provides a noninvasive approach for extracting pixel-wise electrical properties by processing the B1 field mapping data. However, our current understanding of the biophysical mechanisms underlying changes in electrical properties at the microscopic cellular level during pathogenesis remains incomplete. In this study, an inhomogeneous liver model was developed to establish a linear correlation between fat fraction and electrical properties. We further fit the correlation of liver phantoms with different fat fractions of 0%, 1%, 9%, 17%, 25%, 30%, and 50% (R2 > 0.93). In addition, an inhomogeneous liver phantom was fabricated and measured through MR-EPT at 128 MHz (3 T). The outcomes of this research have the potential to bridge the gap between microscopic lesions and pixel-wise MR-EPT images, offering a feasible method for extracting electrical properties through fat quantification techniques like MRI-Dixon technique.
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