Cordycepin's therapeutic potential: in vivo transport, transbilayer diffusion and anti‐aging effects

Abstract BACKGROUND Cordycepin (3′‐deoxyadenosine) is a bioactive compound known for its numerous beneficial properties, including antioxidant, anti‐aging and antitumor effects. Despite its promising therapeutic potential, the in vivo transport mechanisms of cordycepin remain inadequately understood. Previous studies have highlighted its biological activity, but there is limited information regarding its transport and distribution, as well as how it interacts with biological systems to exert these effects. The present study explored the transport mechanisms of cordycepin, specifically its interaction with bovine serum albumin (BSA) transporters and 1,2‐dipalmitoyl‐sn‐glycero‐3‐phosphocholine (DPPC) liposomes, and assessed its anti‐aging effects through cellular experiments. RESULTS The study demonstrates that cordycepin effectively interacts with DPPC liposomes, improving its therapeutic efficacy. Spectral analysis shows strong binding between cordycepin and transporters, aiding its distribution in the bloodstream and targeted accumulation in tissues. Additionally, cellular tests reveal that cordycepin inhibits butyl hydroperoxide‐induced cellular senescence in a dose‐dependent manner. CONCLUSION The interaction of cordycepin with BSA transporters and DPPC liposomes enhances its distribution and therapeutic potential. The compound also shows promise as an anti‐aging agent by reducing cellular senescence. These findings provide insight into cordycepin's in vivo behavior and suggest strategies to enhance its pharmacological effectiveness. © 2025 Society of Chemical Industry.