Mechanism of HDAC2 regulating Nrf2 acetylation level in neuronal ferroptosis of neonatal rats with hypoxic-ischemic brain injury

OBJECTIVE: We investigated the mechanism of histone deacetylase 2 (HDAC2) modulating nuclear factor erythroid 2-related factor 2 (Nrf2) acetylation level in neuronal ferroptosis of hypoxic-ischemic brain injury (HIBI) neonatal rats. METHODS: , Nrf2 acetylation, and nuclear Nrf2 in hippocampal tissues were determined. RESULTS: . Inhibition of HDAC2 partially ameliorated neuronal ferroptosis in HIBI neonatal rats. HDAC2 regulated Nrf2 expression and repressed Nrf2 nuclear translocation by mediating Nrf2 deacetylation. Inhibition of Nrf2 partially reversed the ameliorative effect of HDAC2 on neuronal ferroptosis in HIBI neonatal rats. CONCLUSION: HDAC2 modulated neuronal ferroptosis in HIBI neonatal rats by mediating Nrf2 deacetylation.