免疫疗法
免疫系统
癌症研究
肿瘤微环境
免疫
癌症
癌症免疫疗法
转移
免疫检查点
肝癌
免疫学
CD36
生物
医学
肝细胞癌
内科学
受体
作者
Sheue‐Fen Tzeng,Yi-Ru Yu,Jaeoh Park,Janusz von Renesse,Huey-Wen Hsiao,Chen-Hsuan Hsu,Josep Garnica,Jintian Chen,Lu-Ting Chiu,Jonas Santol,Tse-Yu Chen,Pei-Han Chung,Lana E. Kandalaft,Patrick Starlinger,Cheng‐En Hsieh,Ming‐Chin Yu,Pei‐Wen Hsiao,Santiago J. Carmona,Hung-Kai Chen,Zhen Meng
出处
期刊:Cancer Discovery
[American Association for Cancer Research]
日期:2025-04-28
卷期号:15 (8): 1676-1696
被引量:17
标识
DOI:10.1158/2159-8290.cd-24-1409
摘要
Despite the success of cancer immunotherapies, like immune checkpoint inhibitors, many patients still fail to demonstrate significant responses because of metabolic constraints in tumors. PLT012 rejuvenates antitumor immunity by targeting metabolic pathways to reprogram the immune landscape of liver cancer and liver metastasis, with potential to influence future HCC immunotherapy.
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