Palladium (II)/Lewis Acid Catalyzed Oxidative Olefination of 2-Benzamidopyridine 1-Oxide with Acrylates: Synthesis of Isoindolinones

This work describes the development of a heterobimetallic Pd( ii )/Cu( ii )-catalyzed C–H olefination of 2-benzamidopyridine 1-oxide with acrylates followed by intramolecular aza-Michael addition to construct the desired isoindolinone core.