Palladium( ii )/Lewis acid catalyzed oxidative olefination of 2-benzamidopyridine 1-oxide with acrylates: synthesis of isoindolinones

A palladium(II)/Lewis acid-catalyzed C-H olefination of 2-benzamidopyridine 1-oxide with acrylates followed by intramolecular aza-Michael addition for the synthesis of isoindolinones has been developed. The use of a heterobimetallic Pd(II)/Cu(II) catalyst enhances the efficiency of the reaction, enabling the synthesis of a potential anti-sedative agent.