铀酰
化学
铀
齿合度
配体(生物化学)
硝酸铀酰
螯合作用
核化学
放射化学
锕系元素
肉桂酸
无机化学
金属
生物化学
有机化学
受体
材料科学
冶金
离子
作者
Yawen Liu,Bin Zhao,Pimo He,Zeru Wang,Ke Tang,Zhiwei Mou,Yi Tan,Linzhen Wu,Peng Huang,LI Xiao-an,Lin Zhu,Tao Duan
标识
DOI:10.1021/acs.inorgchem.4c00610
摘要
Uranium accumulation in the kidneys and bones following internal contamination results in severe damage, emphasizing the pressing need for the discovery of actinide decorporation agents with efficient removal of uranium and low toxicity. In this work, cinnamic acid (3-phenyl-2-propenoic acid, CD), a natural aromatic carboxylic acid, is investigated as a potential uranium decorporation ligand. CD demonstrates markedly lower cytotoxicity than that of diethylenetriaminepentaacetic acid (DTPA), an actinide decorporation agent approved by the FDA, and effectively removes approximately 44.5% of uranyl from NRK-52E cells. More importantly, the results of the prompt administration of the CD solution remove 48.2 and 27.3% of uranyl from the kidneys and femurs of mice, respectively. Assessments of serum renal function reveal the potential of CD to ameliorate uranyl-induced renal injury. Furthermore, the single crystal of CD and uranyl compound (C9H7O2)2·UO2 (denoted as UO2-CD) reveals the formation of uranyl dimers as secondary building units. Thermodynamic analysis of the solution shows that CD coordinates with uranyl to form a 2:1 molar ratio complex at a physiological pH of 7.4. Density functional theory (DFT) calculations further show that CD exhibits a significant 7-fold heightened affinity for uranyl binding in comparison to DTPA.
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