Three new compounds from Nardostachys jatamansi

Three undescribed compounds including (8S)-neonardochinone B (1), (2E,4E,6E)-4-methylocta-2,4,6-trienedioic acid (2) and narchinol D (3), along with three known sesquiterpenoids kanshone A (4), kanshone K (5) and kanshone L (6) were isolated from the roots of Nardostachys jatamansi. Their structures were elucidated by comprehensive spectroscopic analysis, including mass spectrometry (MS), infrared (IR) spectroscopy, and one- and two-dimensional nuclear magnetic resonance (NMR) spectroscopy. Notably, compounds 1, 2 and 6 demonstrated neuroprotective effects at 10 μM concentration against glutamate (Glu)-induced cytotoxicity in SH-SY5Y neuronal cells.