Near-infrared light-activated lidocaine microneedle patch for rapid local anesthesia

Rationale: Effective local anesthesia with rapid onset and minimal invasiveness is essential for certain minor surgeries, such as aesthetic procedures, but remains difficult to achieve with conventional local anesthesia. Methods: studies were conducted to assess biosafety and invasiveness, while behavioral tests were performed in a rat plantar incision model to evaluate the onset and duration of anesthesia. Results: studies. Conclusions: The LiH/MXene@MNs platform offers an efficient, minimally invasive, and safe alternative to traditional local anesthesia techniques. This approach holds strong potential for use in minimally invasive aesthetic procedures, providing a promising solution for rapid and effective pain management.