MTRR公司
亚甲基四氢叶酸还原酶
双相情感障碍
蛋氨酸合酶
精神分裂症(面向对象编程)
痴呆
萧条(经济学)
精神科
医学
自闭症
胱硫醚β合酶
同型半胱氨酸
维生素D与神经学
疾病
维生素B12
认知
心理学
生物信息学
内科学
遗传学
生物
蛋氨酸
等位基因
基因
氨基酸
经济
宏观经济学
作者
Ellen Siobhan Mitchell,Nelly Conus,Jim Kaput
标识
DOI:10.1016/j.neubiorev.2014.08.006
摘要
The B vitamins folic acid, vitamin B12 and B6 are essential for neuronal function, and severe deficiencies have been linked to increased risk of neurodevelopmental disorders, psychiatric disease and dementia. Polymorphisms of genes involved in B vitamin absorption, metabolism and function, such as methylene tetrahydrofolate reductase (MTHFR), cystathionine β synthase (CβS), transcobalamin 2 receptor (TCN2) and methionine synthase reductase (MTRR), have also been linked to increased incidence of psychiatric and cognitive disorders. However, the effects of these polymorphisms are often quite small and many studies failed to show any meaningful or consistent associations. This review discusses previous findings from clinical studies and highlights gaps in knowledge. Future studies assessing B vitamin-associated polymorphisms must take into account not just traditional demographics, but subjects’ overall diet, relevant biomarkers of nutritional status and also analyze related genetic factors that may exacerbate behavioral effects or nutritional status.
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