达帕格列嗪
化学
2型糖尿病
肾葡萄糖重吸收
糖尿病
钠
药理学
内分泌学
协同运输机
医学
内科学
有机化学
作者
Wei Meng,Bruce A. Ellsworth,Alexandra A. Nirschl,Peggy J. McCann,Manorama M. Patel,Ravindar N. Girotra,Gang Wu,Philip M. Sher,Eamonn P. Morrison,Scott A. Biller,Robert Zahler,Prashant P. Deshpande,Annie Pullockaran,Deborah Hagan,Nathan Morgan,Joseph R. Taylor,Mary T. Obermeier,W. Griffith Humphreys,Ashish K. Khanna,Lorell Discenza
摘要
The C-aryl glucoside 6 (dapagliflozin) was identified as a potent and selective hSGLT2 inhibitor which reduced blood glucose levels in a dose-dependent manner by as much as 55% in hyperglycemic streptozotocin (STZ) rats. These findings, combined with a favorable ADME profile, have prompted clinical evaluation of dapagliflozin for the treatment of type 2 diabetes.
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