Spacecraft-environment interactions are defined as the responses of a spacecraft surface to a charged-particle environment. This response can influence spacecraft system performance. Interactions can be divided into two broad categories: spacecraft passive, in which the environment acts on the spacecraft; and spacecraft active, in which the spacecraft causes the interaction. Passive interactions include the spacecraft-charging phenomenon. Active interactions include the relatively new interactions arising from the use of very large spacecraft and space power systems in future missions. To illustrate active interactions, a large power system operating at elevated voltages is considered. Possible interactions are described, available experimental data are reviewed, and the effect on power system performance is estimated.