The Therapeutic Potential of Angiotensin-(1-7) as a Novel Renin- Angiotensin System Mediator

In this review, we show Angiotensin-(1-7) as a novel Renin Angiotensin System mediator that antagonizes cardiovascular and proliferative effects of Angiotensin II and exerts complex renal actions. We also speculate the possibility of new drugs for the treatment of cardiovascular, genitourinary and hepatic diseases by interfering with ACE2- Angiotensin-(1-7)-Mas axis. Keywords: Angiotensin-(1-7), Mas receptor, Angiotensin-converting enzyme 2, Angiotensin II, AVE 0991, Angiotensin antagonists, Renin-Angiotensin System