Chemokine Receptor CXCR4−Targeted PET/CT With 68Ga-Pentixafor Shows Superiority to 18F-FDG in a Patient With Waldenström Macroglobulinemia

Abstract A 69-year-old woman diagnosed with Waldenström macroglobulinemia (WM) was referred for 18 F-FDG and 68 Ga-Pentixafor PET/CT for evaluation of the disease. Extensive involvement of WM with intense radioactivity in the bone marrow and lymph nodes was found in 68 Ga-Pentixafor PET/CT. However, in 18 F-FDG PET/CT, the lesions showed significantly lower tracer uptake. Given the superiority of 68 Ga-Pentixafor in detecting WM lesions to 18 F-FDG in this patient, 68 Ga-Pentixafor PET/CT might be a promising imaging modality in assessment of tumor burden of WM in future studies.