SIRT3
锡尔图因
NAD+激酶
脂肪肝
烟酰胺腺嘌呤二核苷酸
氧化应激
西妥因1
生物
药理学
医学
疾病
生物化学
内科学
酶
基因
下调和上调
作者
Jia Yu,C Chen,W X Wang
出处
期刊:PubMed
日期:2016-12-20
卷期号:24 (12): 948-951
标识
DOI:10.3760/cma.j.issn.1007-3418.2016.12.017
摘要
The deacetylase Sirtuin 3 (SIRT3) is a member of the Sirtuins mainly located in the mitochondrial matrix, and as a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, it can regulate cellular energy metabolism and oxidative stress-related pathways. The liver is the largest solid organ in the human body and plays a very important role in substance metabolism. Based on the features of SIRT3, it is closely associated with the development and progression of certain liver diseases. This article reviews the research advances in the role of SIRT3 in non-alcoholic fatty liver disease, liver cancer, and hepatic ischemia-reperfusion injury.
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