Catalytic Asymmetric Reductive Condensation of N–H Imines: Synthesis of C2‐Symmetric Secondary Amines

Abstract A highly diastereoselective and enantioselective Brønsted acid catalyzed reductive condensation of N−H imines was developed. This reaction is catalyzed by a chiral disulfonimide (DSI), uses Hantzsch esters as a hydrogen source, and delivers useful C 2 ‐symmetric secondary amines.