医学
危险系数
糖尿病
内科学
置信区间
心脏病学
血运重建
不利影响
比例危险模型
倾向得分匹配
冲程(发动机)
心肌梗塞
内分泌学
机械工程
工程类
作者
Haiyang Gao,Erli Zhang,Qingrong Liu,Hongqiu Gu,Heng Zhang,Zhe Zheng,Yuejin Yang,Runlin Gao,Yongjian Wu
出处
期刊:Coronary Artery Disease
[Ovid Technologies (Wolters Kluwer)]
日期:2017-03-01
卷期号:28 (2): 151-158
被引量:4
标识
DOI:10.1097/mca.0000000000000441
摘要
Objective The aim of this study was to evaluate the impact of diabetes duration on long-term clinical outcomes after drug-eluting stent (DES) implantation or coronary artery bypass grafting (CABG). Methods A total of 820 diabetic patients treated with initial DES (n=451) or CABG (n=369) were consecutively enrolled in this single-center follow-up study. The main outcomes included major adverse cardiac events and major adverse cardiac or cerebrovascular events (MACCEs). Cox regression analysis with propensity adjustment was used for data analysis. Results Three-year risks of major adverse cardiac events were significantly higher in the DES group compared with the CABG group irrespective of whether the diabetes durations were less or more than 5 years [hazard ratio (HR) 2.27, 95% confidence interval (CI) 1.19–4.31, P=0.01; HR 3.73, 95% CI 2.72–10.12, P<0.01; P for interaction=0.28]. A similar trend was observed for repeat revascularization. However, CABG was associated with increased risk of stroke, especially in the patients with diabetes duration of at least 5 years (HR 0.02, 95% CI 0.002–0.12, P<0.01). Three-year risk of MACCEs was significantly higher in the DES group in patients with diabetes duration of at least 5 years (HR 2.13, 95% CI 1.34–3.39, P<0.01), but not for those less than 5 years (HR 1.03, 95% CI 0.65–1.63, P=0.91). A statistically significant interaction between diabetes duration and treatment strategy was found for MACCEs (P for interaction=0.04). Conclusion Short diabetes duration (<5 years) was associated with equal risk of MACCEs among stable coronary artery disease patients with DES and CABG, emphasizing the need to consider the duration of diabetes when determining the best strategy for patients undergoing coronary revascularization.
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