医学
生物标志物
内科学
糖皮质激素受体
胃肠病学
接收机工作特性
抗体
免疫球蛋白E
白细胞介素2
免疫学
受体
生物化学
化学
作者
Tomohiro Handa,Shoko Matsui,Hajime Yoshifuji,Yuzo Kodama,Hiroshi Yamamoto,Seijiro Minamoto,Yuko Waseda,Yasuharu Sato,Keishi Kubo,Tsuneyo Mimori,Tsutomu Chiba,Toyohiro Hirai,Michiaki Mishima
标识
DOI:10.1080/14397595.2017.1416739
摘要
Objectives: Serum soluble interleukin-2 (IL-2) receptor (sIL-2R) might reflect disease activity in immunoglobulin G4-related disease (IgG4-RD). We aimed to elucidate the clinical significance of blood markers, including sIL-2R, in patients with IgG4-RD. Methods: We enrolled 59 patients with IgG4-RD and investigated the association between blood markers (white blood cells, C-reactive protein, sIL-2R, IgG, IgG4, IgE, total hemolytic complement), and clinical indices. Results: At baseline, serum sIL-2R (Rs = 0.532, p < .001) and IgG4 (Rs = 0.545, p < .001) levels showed significant correlation to the number of organs involved. During follow-up period (median, 70 months; range, 7–195 months), 40 patients were treated with corticosteroids. Receiver operating characteristic (ROC) analysis showed that baseline sIL-2R levels most accurately predicted patients requiring glucocorticoid treatment (area under the ROC curve, 0.807). Among the 46 patients who improved, sIL-2R and IgG4 levels decreased in 42 and 41 patients, respectively. Among them, serum sIL-2R levels decreased to a normal range in 42 patients (91%), whereas IgG4 levels normalized in 19 (41%). Conclusion: The serum sIL-2R level is a potential biomarker for IgG4-RD that may reflect the number of involved organs and may predict patients requiring glucocorticoid treatment.
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