胶质瘢痕
再生(生物学)
神经科学
小胶质细胞
轴突
神经胶质
生物
星形胶质细胞
中枢神经系统
细胞生物学
炎症
免疫学
作者
Katrina L. Adams,Vittorio Gallo
标识
DOI:10.1038/s41593-017-0033-9
摘要
Injury or disease to the CNS results in multifaceted cellular and molecular responses. One such response, the glial scar, is a structural formation of reactive glia around an area of severe tissue damage. While traditionally viewed as a barrier to axon regeneration, beneficial functions of the glial scar have also been recently identified. In this Perspective, we discuss the divergent roles of the glial scar during CNS regeneration and explore the possibility that these disparities are due to functional heterogeneity within the cells of the glial scar-specifically, astrocytes, NG2 glia and microglia.
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