氨苄西林
大肠杆菌
维拉帕米
红霉素
化学
抗菌活性
微生物学
多重耐药
抗生素
药理学
生物
细菌
生物化学
钙
基因
有机化学
遗传学
作者
Gyorgyi Gunics,Sándor Farkas,Noboru Motohashi,Anamik Shah,Gaveriya Harsukh,Masami Kawase,Joseph Molnár
标识
DOI:10.1016/s0924-8579(02)00159-0
摘要
Eleven analogues of nifedipine (NP) showed synergistic interactions with ampicillin (Ap) and erythromycin (Er) on Escherichia coli K12LE140/F'lac. The antibacterial effect of Ap was enhanced by most analogues but compound (G9) and (+/-)-verapamil (VP) were antagonistic. Two of the 11 compounds (G7, G8) were synergistic with Er and four were additive. With a sensitive clinical isolate of E. coli Gy-1/Ap(sens)Er(res), compound G1 antagonized the antibacterial effect of Ap and a synergistic effect was found in the combination of Er with G4, G5, G6 or G7. None of the drugs had any effect on a multidrug resistant (MDR) clinical isolate of E. coli Gy-2/Ap(res)Er(res).
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