化学
激素受体
受体
化学合成
药理学
内分泌学
内科学
兴奋剂
激素
甲状腺
组合化学
立体化学
生物化学
体外
癌症
医学
乳腺癌
作者
Naoki Takahashi,Koji Maeda,Yukiyasu Asano,Nozomi Watanabe
标识
DOI:10.1016/j.bmc.2013.11.001
摘要
A series of 1-benzylindole-based TRβ agonists were prepared and evaluated. Compounds 11b' and 11c' were found to have cholesterol-lowering in a rat model with marginal effects on cardiac function and HPT axis. The present work illustrates the potential use of indoles as inner ring isosteres.
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