尿素循环
神经化学
认知
神经科学
认知障碍
医学
心理学
生物
遗传学
氨基酸
精氨酸
作者
Andrea Gropman,Mark L. Batshaw
标识
DOI:10.1016/j.ymgme.2003.11.016
摘要
Despite treatment, cognitive and motor deficits are common in individuals with inherited urea cycle disorders. However, the extent to which the deficits involve specific cognitive or sensorimotor domains is unknown. Furthermore, little is known about the neurochemical basis of cognitive impairment in these disorders. This paper reviews studies of cognitive and motor dysfunction in urea cycle disorders, and discusses potential venues for investigation of the underlying neural basis that may elucidate these defects. Such methods of investigation may serve as a model for studying the relationship between genes, biochemical markers, brain function, and behavior in other metabolic diseases.
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