GALNT4 Predicts Clinical Outcome in Patients with Clear Cell Renal Cell Carcinoma

No AccessJournal of UrologyInvestigative Urology1 Nov 2014GALNT4 Predicts Clinical Outcome in Patients with Clear Cell Renal Cell Carcinoma Yidong Liu, Weisi Liu, Le Xu, Haiou Liu, Weijuan Zhang, Yu Zhu, Jiejie Xu, and Jianxin Gu Yidong LiuYidong Liu Key Laboratory of Glycoconjugate Research, Ministry of Health, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Shanghai Medical College of Fudan University, Shanghai, People's Republic of China Equal study contribution. More articles by this author , Weisi LiuWeisi Liu Key Laboratory of Glycoconjugate Research, Ministry of Health, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Shanghai Medical College of Fudan University, Shanghai, People's Republic of China Equal study contribution. More articles by this author , Le XuLe Xu Department of Urology, Zhongshan Hospital, Shanghai Medical College of Fudan University, Shanghai, People's Republic of China Equal study contribution. More articles by this author , Haiou LiuHaiou Liu Key Laboratory of Glycoconjugate Research, Ministry of Health, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Shanghai Medical College of Fudan University, Shanghai, People's Republic of China More articles by this author , Weijuan ZhangWeijuan Zhang Department of Immunology, School of Basic Medical Sciences, Shanghai Medical College of Fudan University, Shanghai, People's Republic of China More articles by this author , Yu ZhuYu Zhu Department of Urology, Ninth People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, People's Republic of China More articles by this author , Jiejie XuJiejie Xu Key Laboratory of Glycoconjugate Research, Ministry of Health, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Shanghai Medical College of Fudan University, Shanghai, People's Republic of China More articles by this author , and Jianxin GuJianxin Gu Key Laboratory of Glycoconjugate Research, Ministry of Health, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Shanghai Medical College of Fudan University, Shanghai, People's Republic of China More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.04.084AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We investigated the clinical significance of GALNT4 expression in patients with clear cell renal cell carcinoma. Materials and Methods: Enrolled in this study were 104 patients treated with curative nephrectomy at Zhongshan Hospital, Shanghai during 2004. Of the cohort 23 patients died of disease, 33 experienced recurrence and 3 died of another cause. GALNT4 density was assessed by immunohistochemistry in patient specimens. Univariate and multivariate Cox models, and ROC analysis were used to analyze the impact of prognostic factors on overall and relapse-free survival. Kaplan-Meier analysis with the log rank test was done to compare clinical outcomes between subgroups. Results: Intratumor GALNT4 expression was significantly lower than peritumor expression. Low GALNT4 expression was associated with poor overall and relapse-free survival (p = 0.001 and 0.004, respectively). Intratumor GALNT4 expression, which negatively correlated with tumor size (p = 0.032), necrosis (p = 0.013) and TNM stage (p = 0.017), was an independent prognostic indicator for overall and relapse-free survival (HR 3.088, p = 0.020 and 2.173, p = 0.047, respectively). Extending the TNM staging system according to GALNT4 expression showed a better prognostic value for overall and relapse-free survival (AUC 0.786, p = 0.029 and 0.761, p = 0.040, respectively). Conclusions: Intratumor GALNT4 expression is a potential independent prognostic factor for overall and relapse-free survival in patients with clear cell renal cell carcinoma. Further external validation and functional analysis should be performed to assess its potential prognostic and therapeutic value in patients with clear cell renal cell carcinoma. References 1 : Estimates of cancer incidence in China for 2000 and projections for 2005. Cancer Epidemiol Biomarkers Prev2005; 14: 243. 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Google Scholar © 2014 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 192Issue 5November 2014Page: 1534-1541Supplementary Materials Advertisement Copyright & Permissions© 2014 by American Urological Association Education and Research, Inc.Keywordsmortalitycarcinomarenal cellprognosispolypeptide N-acetylgalactosaminyltransferasekidneyAcknowledgmentsProf. Yumei Wen, Shanghai Medical College of Fudan University provided suggestions.MetricsAuthor Information Yidong Liu Key Laboratory of Glycoconjugate Research, Ministry of Health, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Shanghai Medical College of Fudan University, Shanghai, People's Republic of China Equal study contribution. More articles by this author Weisi Liu Key Laboratory of Glycoconjugate Research, Ministry of Health, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Shanghai Medical College of Fudan University, Shanghai, People's Republic of China Equal study contribution. More articles by this author Le Xu Department of Urology, Zhongshan Hospital, Shanghai Medical College of Fudan University, Shanghai, People's Republic of China Equal study contribution. More articles by this author Haiou Liu Key Laboratory of Glycoconjugate Research, Ministry of Health, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Shanghai Medical College of Fudan University, Shanghai, People's Republic of China More articles by this author Weijuan Zhang Department of Immunology, School of Basic Medical Sciences, Shanghai Medical College of Fudan University, Shanghai, People's Republic of China More articles by this author Yu Zhu Department of Urology, Ninth People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, People's Republic of China More articles by this author Jiejie Xu Key Laboratory of Glycoconjugate Research, Ministry of Health, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Shanghai Medical College of Fudan University, Shanghai, People's Republic of China More articles by this author Jianxin Gu Key Laboratory of Glycoconjugate Research, Ministry of Health, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Shanghai Medical College of Fudan University, Shanghai, People's Republic of China More articles by this author Expand All Advertisement PDF downloadLoading ...