α-Csp3–H Bond Functionalization of Simple Ethers in Radical Reactions

Abstract The direct α-Csp3–H functionalization of simple ethers is a vital strategy among radical reactions. This review discusses their applications according to the starting materials: (1) reactions with alkenes or alkynes; (2) reactions with other unsaturated compounds; and (3) reactions with nucleophilic partners. Mechanisms like radical addition, C–H activation, elimination, metal-catalyzed coupling, cyclization, oxidation, and rearrangement will be analyzed herein. 1 Introduction 2 Reactions with Alkenes or Alkynes 3 Reactions with Other Unsaturated Compounds 4 Reactions with Nucleophilic Partners 5 Oxidation of Ethers 6 Conclusions