粪肠球菌
癌变
失调
脱氧胆酸
肠道菌群
微生物群
肝病
肝癌
免疫学
微生物学
致癌物
生物
胃肠病学
医学
癌症研究
癌症
胆汁酸
肝细胞癌
基因
生物信息学
大肠杆菌
遗传学
内分泌学
作者
Noriho Iida,Eishiro Mizukoshi,Tatsuya Yamashita,Masahiro Yutani,Jun Seishima,Ziyu Wang,Kuniaki Arai,Hikari Okada,Taro Yamashita,Yoshio Sakai,Yusuke Masuo,Rina Agustina,Yukio Kato,Yukako Fujinaga,Masanobu Oshima,Masao Honda,François Lebreton,Michael S. Gilmore,Shuichi Kaneko
出处
期刊:Nature cancer
[Springer Nature]
日期:2021-09-27
卷期号:2 (10): 1039-1054
被引量:27
标识
DOI:10.1038/s43018-021-00251-3
摘要
Gut dysbiosis is observed in chronic hepatobiliary diseases and is frequently associated with liver carcinogenesis; however, the extent and specific mechanisms triggered by alterations in the microbiota mediating tumorigenesis in these patients remain unclear. Here we show that Enterococcus faecalis is abundant in the microbiota of patients with hepatitis C virus-related chronic liver disease. Xenotransplantation of gut microbiota from these patients increased the number of spontaneous liver tumors in mice and enhanced susceptibility to liver carcinogens. Hepatic colonization by gelE-positive E. faecalis increased liver expression of proliferative genes in a TLR4-Myd88-dependent manner, leading to liver tumorigenesis. Moreover, decreased fecal deoxycholic acid levels were associated with colonization by E. faecalis. Overall, these data identify E. faecalis as a key promoter of liver carcinogenesis.
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