Electrochemical and optical biosensors based on multifunctional MXene nanoplatforms: Progress and prospects

Two-dimensional (2D) transition metal carbides, carbonitrides, and nitrides (MXene) have emerged as a rising family of atomic layered nanomaterials which undergoes intensive investigations in interdisciplinary applications. The large surface-to-volume ratio, excellent mechanical strength, desirable biocompatibility, along with tunable electronic and optical properties, render 2D MXenes exceptional attractive as versatile nanoplatforms for biosensing. Herein, advanced progress and novel paradigms of MXene-based biosensors are reviewed, focusing on the combination of MXenes with various detection techniques that promotes target recognition and signal transducing. Regarding the nature of transducing signals, MXene-based biosensors are categorized into two groups where MXenes serve as electrical platforms or optical platforms, respectively. The merits of MXenes are critically compared with other 2D materials to illustrate the distinctive advantages of MXenes in biosensing, while challenges such as environmental vulnerability was discussed to guide the sensor design. Facing with the rapid development of wearable electronics and internet of medical things, as well as escalating demanding in precision medicine, perspectives are provided to elucidate the potential of MXenes in propelling advances in these trending biomedical applications. • 2D MXenes as versatile nanoplatforms for electrochemical and optical biosensing. • MXenes are compared with TMDs and graphene to demonstrate its merits. • Combinations of MXenes with various detection techniques are discussed. • Challenges of MXene-based biosensors are analyzed. • Prospects in wearable biosensors and sensing-medical intervention are discussed.