DNA DAMAGE AND DECREASE OF SPERM QUALITY IN MEN OCUPATIONALLY EXPOSED TO POLYCYCLIC AROMATIC HYDROCARBONS (PAH’s)

作者
Edgar Olivas‐Calderón,Rogelio Recio Vega,Rebeca Isabel Martínez Salinas,Guadalupe García Arenas,Jorge Antonio Espinosa Fematt,Martha Patricia Gallegos‐Arreola,Guadalupe Ocampo Gómez
出处
期刊:Environmental health perspectives [Environmental Health Perspectives]
卷期号:2011 (1)
标识
DOI:10.1289/isee.2011.00223
摘要

Background and aims: Over the last decade, concerns have been mounting over declining levels of semen quality (1). Polycyclic aromatic hydrocarbons (PAHs) constitute a group of genotoxic, lipophilic, and endocrine-disrupting chemicals that are distributed in the environment. The aim was to evaluate the association between the urinary levels of 1-hydroxypyrene with the DNA damage, with sperm quality and with the frequency of CYP1A1, GSST1 and GSTM1 polymorphisms. Methods: A cross-sectional study was designed to evaluate the adverse effects of PHAs. A total of 71 subjects, 36 occupationally exposed and 35 unexposed men were included in our study. Semen, blood and urine samples were taken to volunteers to evaluate: sperm quality, 1-hydroxypyrene urinary levels (Biomarker of exposure PAH’s), DNA damage and the frequency of polymorphism CYP1A1, GSTT1 y GSTM1. Results: DNA damage was significantly higher in occupationally exposed subjects (p <0.05). The frequency of genotypes of the enzymes tested was not statistically different between both groups. The sperm quality was significantly lower in the exposed group (p <0.05). 1-hydroxypyrene urinary levels were higher in the exposed group (p=0.01). Sperm/ml, total count of sperm and CYP1A1 (m4) polymorphism were negatively associated with 1-hydroxypyrene. Conclusion: PAH exposure decreases sperm quality and induce DNA damage.

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