嵌合抗原受体
医学
免疫分型
弥漫性大B细胞淋巴瘤
细胞因子释放综合征
癌症研究
淋巴瘤
CD19
免疫学
耐火材料(行星科学)
抗原
肿瘤科
T细胞
内科学
免疫系统
生物
天体生物学
作者
Fang Bao,Wei Wan,Ting He,Feifei Qi,Guanghua Liu,Kai Hu,Xiangjun Lu,Ping Yang,Fang Dong,Jing Wang,Hongmei Jing
标识
DOI:10.1038/s41417-018-0073-7
摘要
Patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) have a poor prognosis. Chimeric antigen receptor (CAR) modified T cells targeting CD19 hold great promise to improve the complete response rates of DLBCL patients compared with conventional therapies. Here, we conducted a clinical trial to evaluate the efficacy and safety of CAR-T cells. Five patients with relapsed or refractory DLBCL were treated with autologous T cells expressing the 19-41BBz chimeric antigen receptor (CAR) specifically targeted the CD19 antigen (IM19 CAR-T). The development of cytokine release syndrome (CRS) was observed. And the efficacy of IM19 CAR-T cell treatment was measured with positron emission tomography (PET)-computed tomography (CT). Of the four patients evaluable for response, two obtained complete responses (CRs), one obtained partial response (PR), and one had stable disease (SD). Remarkably, among the five patients, only one developed grade 2 CRS while the others only elicited grade 1 CRS. Additionally, the efficacy and safety of IM19 CAR-T cells were correlated with the peak blood level and persistence of CAR-T cells, as well as the immunophenotype of T-cell subsets. Overall, this study indicates the feasibility and effectiveness of IM19 CAR-T cells in the treatment of refractory or relapsed diffuse large B-cell lymphoma.
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